Update on the development of a novel dry cow therapy using a bismuth-based intramammary teat seal in combination with the bacteriocin lacticin 3147
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چکیده
: Public concerns over the widespread prophylactic use of antibiotics have led to a search for alternatives to dry cow therapy for the prevention of intramammary infections. A popular alternative is to infuse a teat seal at drying-off. The teat seal is a viscous non-antibiotic formulation and when it is infused into the teat canal and the teat sinus it forms an internal seal that provides a physical barrier to invasion by mastitis-causing pathogens. Enhancement of teat seal formulations may be achieved using non-antibiotic additives such as bacteriocins, potent proteins produced by some bacteria that have the ability to kill other microorganisms. This paper traces the history of investigations at Moorepark Research Centre into the efficacy of teat seal plus lacticin 3147, a bacteriocin produced by Lactococcus lactis DPC3147, in the prevention of intramammary infections in dry cows. Indications from on-going investigations are that a dry cow formulation combining the two products has considerable potential as a non-antibiotic prophylactic product.
منابع مشابه
The Use of a Bismuth-based Teat Seal and the Bacteriocin Lacticin 3147 to Prevent Dry Period Mastitis in Dairy Cows
Mastitis in dry cows has traditionally been controlled with long-acting intramammary antibiotic formulations. However, the widespread use of antibiotics, particularly for prophylactic application, is likely to be restricted in the future. As a consequence, there is now a growing requirement for effective alternatives to prevent mastitis. A bismuth-based, intramammary teat seal has recently been...
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Efficacy of a teat dip containing the bacteriocin lacticin 3147 to eliminate Gram-positive pathogens associated with bovine mastitis.
On most dairy farms teat dips are applied to the teats of cows either before or after milking in order to prevent pathogens from gaining access to the mammary gland via the teat canal. In the present experiments, a natural teat dip was developed using a fermentate containing the live bacterium Lactococcus lactis DPC 3251. This bacterium produces lacticin 3147, a two-component lantibiotic which ...
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Presence of mastitis in pregnant as well as unbred dairy heifers can adversely affect the development of milk-producing tissues, leading to less than maximal milk production and increased SCC during their first lactation. Use of nonlactating cow therapy or teat sealants have been beneficial in curing existing IMI and preventing new IMI from developing. When used together, the combination of the...
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